A Semi-Synthetic Anti-Tumor Drug Obtained Through Alkylation of Major Celandine Alkaloids – Amitozyn

Malaria which is caused by Plasmodium falciparum is that the most virulent style of protozoal infection, resulting in around a 0.5 million deaths annually. Therapy continues to be a key approach in protozoal infection hindrance and treatment. By the widespread parasite drug resistance, identification and development of recent anti-malarial compounds remains a very important task of protozoal infection parasitology. The semi-synthetic drug amitozyn, obtained through alkylation of important celandine (Chelidonium majus) alkaloids with N,N?N?-triethylenethiophosphoramide (ThioTEPA), may be a wide used European people medication for the treatment of varied tumours. However, its anti-malarial impact has never been studied. .

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