volume 7

Multiple-Scale Computational Studies of Redox-Controlled Supramolecular Co-Assembly Nanoplat form: Toward Immunochemotherapy-Driven Antitumor Augment

1. Abstract Programmed cell death protein 1 (PD1)/programmed death ligand 1 (PD-L1) blockades provide an effective and safe therapeutic option in the field of refractory cancer therapy. However, not more than 30% response rate of most cancers seriously impedes their therapeutic efficacy. Previous investigations have proved the effectiveness of combining chemotherapy with immunotherapy for unsatisfactory …

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Cytokine Storm Syndrome in COVID-19 Patients: Characteristics and Diagnosis

1. Abstract Cytokine storm syndrome (CSS) is a critical condition induced by a cascade of cytokine activation, characterized by overwhelming systemic inflammation, hyperferritinaemia, haemodynamic instability and multiple organ failure. At the end of 2019, the disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in Wuhan, China, and rapidly developed into a global …

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Case of Anthrax Abdominal Form in Kazakhstan

1. Introduction Anthrax is a dangerous zoonotic infection that is transmitted from farm animals to humans, when cutting, butchering infected animals, contact with meat and other animal products. Infection occurs by contact, alimentary, aerogenic pathways, while developing corresponding clinical forms – skin /ulcerative, abdominal / intestinal, pulmonary /pneumonic Kazakhstan is an anthrax-endemic territory, cases of …

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Loop –Mediated Isothermal Amplification (LAMP) Based POINT-OF-CARE for Rapid Detection of Pathogens Recent Development and Future Out Look

1. Abstract Infectious diseases, including foodborne diseases, to this day remain a major health threat worldwide. Molecular diagnostics, based on nucleic acid (NA) amplification technologies, are in the forefront for the detection of pathogens. Polymerase chain reaction (PCR) is one of the most widely used methods for nucleic acid amplification in pathogen diagnostic.

Deprescribing of Benzodiazepines in the Elderly Using A 3Es Model: A Patient Centered Approach

1. Abstract Benzodiazepines use in the elderly are associated with morbidity including increased falls, fractures, and mortality. The common reason for re-prescribing benzodiazepine by physicians is dependency. Our project proposal aims to enhance medication safety in the elderly. It requires a multidisciplinary approach and patient-centred care focusing on benzodiazepine deprescribing using the 3Es model of …

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Association between Body Mass Index and Severity According of Classification of Thyroid Cancer

1. Abstract 1.1. Purpose: Obesity is associated with aggressive pathological features and poor clinical outcomes in breast and prostate cancers. However, the associations between excess weight and prognostic factors for thyroid cancer are uncertain. This study aimed to evaluate the associations between body mass index (BMI) and severity according of classification of thyroid cancer. DOI …

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My Lynch Syndrome Survivor’s Story – Duke “C” Colon Cancer While Pregnant

1. Abstract Lynch Syndrome is a familial disease, caused by a germline pathogenic variant in the mismatch repair genes: EPCAM, MLH1, MSH2, MSH6, and PMS2. Lynch Syndrome poses a lifetime-risk for related cancers such as colon, endometrial, ovarian and gastric, due to a DNA sequencing error in codon region MSH2. I (Savard, present author) inherited …

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