The doable use of metal compounds within the treatment of diabetic patients is currently being evaluated. However, antecedently to ascertain the optimum most dose for polygenic disease medical aid, it ought to be taken into consideration that atomic number 23|metal} may be a extremely toxicant element to man and animals. The toxicant effects of metal square measure here reviewed. The tissue metal accumulation, which might mean a further risk of toxicity following prolonged metal administration is additionally mentioned. Recently, it’s been shown that coadministration of salt and TIRON, a good chelator within the treatment of metal intoxication, reduced the tissue accumulation of this component, decreasing the likelihood of toxicant aspect impacts derived from chronic metal administration while not decreasing the hypoglycaemic effect of metal. However, antecedently to assess the effectiveness of this treatment in diabetic patients, a essential valuation of the medicine action of metal and its potential toxicity is clearly required.