Gastrointestinal (GI) cancer, a cancer of various organs of the digestive system, is one among the foremost common cancers across the world. though an oversized style of chemotherapeutical agents are introduced since the previous few decades to combat GI cancer, most of them are terribly high-priced and have facet effects. Therefore, the compounds derived from natural sources, that are thought about to be safe and value effective, are needed. Ginger (Zingiber officinale) is one among the foremost wide used natural product consumed as a spice and medication for treating nausea, dysentery, heartburn, flatulence, diarrhea, loss of craving, infections, cough, and respiratory disease. Experimental studies showed that ginger and its active elements as well as 6-gingerol and 6-shogaol exert metastatic tumor activities against GI cancer.