The aim of this multicenter prospective study was to guage the incidence of invasive flora infections (IFIs) in adult and medical specialty patients with medical specialty malignancies, involving 9 healthcare facility facilities in Southern Italian Republic over a amount of eighteen months. moreover, results of AN environmental microbic police work habitually disbursed in a number of the registered hospitals square measure according. a complete of 589 onco-hematological patients were registered and twenty seven IFIs were documented. the most infections were caused by yeasts, over filiform fungi (overall incidence of two.7% and 1.9%, respectively). The yeasts were in the main described by fungus spp. (87.5%), all isolated by blood cultures; C. parapsilosis was the foremost common species. Among mould infections, the foremost frequent web site was the respiratory organ, with relevancy aspergillosis (81.8%). In six of the ten patients with suspected aspergillosis, the designation was created by the detection of galactomannan and (1,3)-?-d-glucan antigens.