Research Article

Chronic Graft Versus Host Disease: An Update on the Clinical Characterization and Diagnostic Assessment of Cutaneous and Articular Sclerotic Forms

1. Abstract 1.1. Background: Chronic graft-versus-host disease (cGVHD)is a late immune-mediated, and sometimes a severe complication of patients undergoing allogeneic hematopoietic cell transplantation. It is a multisystemic inflammatory disease with variable degree of fibrosis, mainly at cutaneous and often-overlooked musculoskeletal level, which entails a negative impact on the quality of life and physical function of …

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Short Course Oral Digoxin Treatment in Acute Decompensated Heart Failure: A Case Control Study

1. Abstract 1.1. Background: Despite many critical voices regarding its efficacy and safety, digoxin may still have a role in the management of heart failure. The objective of this study was to evaluate the efficacy and safety of a short course digoxin therapy started in the emergency department based on clinical outcome after 30 days …

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A New Panel of DNA Methylation Biomarkers for Screening Colorectal Cancer and Precancerous Lesions in a Chinese Population

1. Abstract 1.1. Aims The identification of tumor-specific DNA methylation patterns in epithelial colorectal cells in feces has emerged as a novel and noninvasive screening method for colorectal cancer (CRC) and precancerous lesions. Our study investigates a new panel of DNA methylation biomarkers with high sensitivity and specificity for the early screening of CRC and …

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Medical Schemes and COVID-19 Related Mortality – South Africa: An Explorative Study

1. Abstract 1.1. Background: The COVID-19 epidemic has adversely affected health systems globally, with some on the verge of collapse, as countries experienced the second wave of the pandemic. Millions of people have died from the pandemic, particularly the elderly and those with comorbidities. COVID-19 infections are also increasing at an alarming rate, with South …

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Flavones and Phenolic Acids as Potential Inhibitor of B16F10 Melanoma Cells Growth and Modulator of Melanogenesis

1. Abstract Pigmentation disorders leading to discoloration or hyperpigmen-tary of underlying tissue occur widely and gain interest. This study is within the framework of strategies under-developing safe com-pounds to modulate melanognonesis pathway. Phenolic acids and flavones were tested for their effects, on the viability in murine melanoma (B16-F10) and in primary human keratinocyte (PHK). Flavones, …

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