Review Article

Complement Enhances the Pathogenesis in Autoinflammation Via Induction of A Pro-Inflammatory Microenvironment

1. Introduction The complement system is a complex part of the innate immune system and consists of more than thirty different proteins present in the plasma and on cell membranes. Complement can be activated via three different pathways and may play a role in triggering the NLRP3 inflammasome [1]. Inflammasomes are essential components in innate …

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Whole Blood Gene Expression Profiling in Response to Treatment for Septic Shock: A Case Report

1. Abstract Septic shock develops as a result of the rapid progression of sepsis due to the massive release of proinflammatory mediators, and is characterized by severe hypotension and tissue hypoxia. While early goal-directed therapy (EGDT) and polymyxin B direct hemoperfusion (PMX-DHP) have shown effectiveness in the treatment of septic shock, no biomarkers are available …

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Rural Healthcare in Light of a Multinational Pandemic: A Global Perspective

1. Abstract Rural healthcare recently came into international spotlight, with recent reported influx of the COVID-19 into rural regions. This article focuses on susceptibilities of the rural population to pandemics and mitigating measures to prevent formation of disease epicentre. Rural Healthcare is by far one of the most neglected areas of medicine. The discrepancies in …

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Cognitive Consequences After Traumatic Brain Injury (TBI)

1. Abstract A traumatic brain injury (TBI) can cause temporary dysfunction of brain cells. More severe craniocerebral injuries can lead to bruising, perforation and tissue rupture, bleeding, and other physical damage to the brain that can lead to long-term complications or death (Bigler, 2016). Consequences of TBI can include physical, sensory, behavioral, and communication disorders, …

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Patients with Multiple Sclerosis and Short-Term Memory Difficulties

1. Abstract Μemory by itself as a function, loses its capabilities with a normal deterioration. However, there are acquired conditions that negatively affect the functions of memory, resulting in dysfunction of its stages. Thus possible damage to the structures of the hemisphere that controls these processes disrupts the comprehension, organization and categorization of the material …

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Allergic Reactions to Covid19 (Sars-Cov-2) Vaccine

1. Background The recent approval of various covid vaccines will result in massive immunization of the public with these vaccines. Cases of allergic reactions such as rashes, urticaria, anaphylaxis have been reported worldwide. The following is a summary, from an allergist’s perspective, of the components found to be present in situations where the patient has …

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Breast DCE-MRI Segmentation for Lesion Detection Using Grammatical Fireworks Algorithm

1. Abstract Breast DCE-MRI segmentation and lesion detection is a crucial image analysis task for cancer detection and tissue characterization. In this paper, a hard-clustering technique with Grammatical Fireworks algorithm (GFWA) is proposed to segment the breast MR images for lesion detection. GFWA is Swarm Programming (SP) method developed for automatic computer program generation in …

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Chronic Maxillary Atelectasis and Silent Sinus Syndrom: Report of Three Cases and Literature Review

1. Abstract Chronic Maxillary Atelectasis (CMA) and Silent Sinus Syndrome (SSS) are conditions that may lie on the same clinical spectrum, since both have similarities in pathophysiology, clinical findings and treatment, although the absence of sinonasal symptoms is the main difference between them. In this study we present three different cases of CMA that were …

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