Review Article

DNA Methylation and Epigenetic Events Underlying Renal Cell Carcinomas

1. Abstract Renal cell carcinoma (RCC) refers to a group of tumors that develop from the epithelium of the kidney tubes, including clear cell RCC, papillary RCC, and chromophobe RCC. Most clear cell renal carcinomas have a large histologic subtype, genetic or epigenetic genetic von Hippel-Lindau (VHL). A comprehensive analysis of the genetic modification genome …

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Height is a Measure of Consumption that Incorporates Nutritional Needs: When and What?

1. Abstract Japan suffered heavily from WWII. Per capita food supply was 1,450 and 1,700 kcal/day in 1946 and 1947, respectively. Japan’s economy quickly recovered to the pre-war level in 10 years after the war, 2,200 kcal/day in average food supply in 1955, making steady progress toward the end of the century. People in Japan, …

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The Role of Genetic Mutations in Genes RUNX1, RUNX1T1, CBFB & MYH11 on Core Binding Factor Acute Myeloid Leukemia

1. Abstract Acute myeloid leukemia (CBF-AML) is one of the causes of hematopoietic tissue (bone marrow) called acute myeloid leukemia. In normal bone marrow, early blood cells called hematopoietic stem cells develop into several types of blood cells: white blood cells (leukocytes) that protect the body against infection, red blood cells (erythrocytes) ) that carry …

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The Risks of Using 2,4‑Dinitrophenol (2,4‑DNP) as a Weight Loss Agent: A Literature Review

1. Abstract The prevalence of obesity has steadily increased in response to changes in diet and physical activity patterns over the past 10 years, becoming one of the leading causes of morbidity and mortality worldwide. In addition, the popularity of social networks has increased social and cultural pressure for the search for the “perfect body”. …

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The Importance of Framing at the Beginning of an Review Dialogue

1. Abstract Long-term care of patients with chronic conditions in general practice rarely focuses on the treatment process. A specific interaction tool, the Review Dialogue (RD), has been developed to integrate patients’ health-related problems/risks as well as coping strategies and to agree upon shared treatment objectives assuming that periodical RDs will help to achieve them. …

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A Rare Presentation of Acute Hemolytic Anemia in a Newborn Infant

1. Abstract Hereditary Elliptocytosis (HE) is a heterogeneous group of inherited Red Blood Cell (RBC) disorders characterized by the presence of elongated, oval, or elliptically shaped RBCs on the peripheral blood smear. Hemolytic anemia in these disordersranges from absent to life-threatening .Transient hemolytic anemia has been reported in neonates with some of the more severe …

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McKittrick-Wheelock Syndrome: A Rare Occasion in a Young Patient

1. Abstract Mckittrick-Wheelock syndrome is a fatal and life threatening diagnosis if no interventions taken on time. It is due to a large distal colon polyp that secretes body salts including sodium and pottasium and thus, causing severe diarrhea and dehydration to the patient. Clinical features of this syndrome are severe dehydration, hypokalemia, hyponatremia, lethargy …

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A Glucagonoma Accompanied with Chronic Necrolytic Migratory Erythema and Multiple Liver Metastasis

1. Abstract Glucagonoma is an extremely rare pNETs, usually presenting with glucagonoma syndrome, Necrolytic Migratory Erythema (NME) is mostly the first clinical manifestation of glucagonoma syndrome. Here we describe a rare case of glucagonoma syndrome accompanied with chronic necrolytic migratory erythema and multiple liver metastasis in a 23-year-old female patient. She complained of a progressive, …

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