Review Article

Radiation Therapy of Thyroid-related Eye Diseases

1. Abstract Thyroid-associated ophthalmopathy (TAO) is an autoimmune disease associated with thyroid-related posterior ocular and perimeter orbital tissue invasive lesions, with a very high incidence of adult orbital disease, with a male and female proportion of about 3:16. Patients with mild diseases have little impact on life, and moderate and severe cases will even lose …

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Management of Acid Base Disorders in Pregnant Woman

1. Abstract The interpretation of the acid-base status is key in medical practice, being its most frequent use in critically ill pregnant patients with any type of hemodynamic alteration such as hemorrhagic shock or septic shock, which happens in most cases, states of hypoperfusion systemic that produce alteration in the acid base state that generates …

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Cytokine Storm Syndrome in COVID-19 Patients: Characteristics and Diagnosis

1. Abstract Cytokine storm syndrome (CSS) is a critical condition induced by a cascade of cytokine activation, characterized by overwhelming systemic inflammation, hyperferritinaemia, haemodynamic instability and multiple organ failure. At the end of 2019, the disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in Wuhan, China, and rapidly developed into a global …

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Complement Enhances the Pathogenesis in Autoinflammation Via Induction of A Pro-Inflammatory Microenvironment

1. Introduction The complement system is a complex part of the innate immune system and consists of more than thirty different proteins present in the plasma and on cell membranes. Complement can be activated via three different pathways and may play a role in triggering the NLRP3 inflammasome [1]. Inflammasomes are essential components in innate …

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Whole Blood Gene Expression Profiling in Response to Treatment for Septic Shock: A Case Report

1. Abstract Septic shock develops as a result of the rapid progression of sepsis due to the massive release of proinflammatory mediators, and is characterized by severe hypotension and tissue hypoxia. While early goal-directed therapy (EGDT) and polymyxin B direct hemoperfusion (PMX-DHP) have shown effectiveness in the treatment of septic shock, no biomarkers are available …

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Rural Healthcare in Light of a Multinational Pandemic: A Global Perspective

1. Abstract Rural healthcare recently came into international spotlight, with recent reported influx of the COVID-19 into rural regions. This article focuses on susceptibilities of the rural population to pandemics and mitigating measures to prevent formation of disease epicentre. Rural Healthcare is by far one of the most neglected areas of medicine. The discrepancies in …

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