Gpbar1 (TGR5), a membrane-bound steroid receptor, is standard for its roles in regulation of energy physiological state and aldohexose metabolism. Here we have a tendency to show that TGR5 could be a suppressor of stomachic neoplastic cell proliferation and migration through antagonizing STAT3 signal pathway. we have a tendency to first of all show that TGR5 activation greatly pent-up proliferation and migration of human stomachic neoplastic cells and powerfully elicited stomachic cancer cell cell death. we have a tendency to then found that TGR5 activation antagonized STAT3 signal pathway through suppressing the phosphorylation of STAT3 and its transcription activity elicited by lipopolysaccharide (LPS) or interleukin-6. TGR5 overexpression with substance treatment pent-up organic phenomenon mediate by STAT3. It suggests that TGR5 antagonizes stomachic cancer proliferation and migration a minimum of partly by inhibiting STAT3 signal.