1. Abstract

Hypertrophic scarring is formed as a result of abnormal wound healing. Efforts have been made to understand the mechanism of hypertrophic scarring for prevention and treatment, mainly by using several model systems. However, animal models do not form effectively hypertrophic scars. Desorption electrospray ionization mass spectrometry imaging enabled label-free elucidation of the spatial distribution of metabolites and lipids in skin tissue samples under ambient conditions of a 36-year-old female. It revealed up-regulation of phospholipid sphingomyelin SM(18:0/16:1), m/z 235.18, and metabolite sphingosine, m/z 310.24, which resulted in skin hardness and defects in the skin barrier function. The scar tissue also showed downregulation of phospholipid cardiolipin CL(62:2), m/z 1322.03 that indicated defects in autophagy function.

1. Abstract
Myeloid neoplasm with eosinophilia is a kind of unusual hematological malignancy. Back in the morphological diagnosis era, the prognosis was generally poor and the best treatment for these cases was allo-stem cell transplantation. According to the classification of eosinophilic diseases revised in the 2008 WHO scheme

1. Abstract
Osseous metaplasia in clear cell renal carcinoma (RCC) is uncommon with few cases reported. We present a case of a 66year-old male in which a right renal lesion in a colorrectal screening was incidentally identified. Computed tomography scan revealed a heterogeneous enhanced mass lesion having areas of hemorrhagic and specks of calcification.

1. Case Study
A) 81 y old male in LTCF with primary learning disability and cervico-dorso-lombarthrosis treated by WHO level 1 painkiller
B) During the absence of the GP, the patient was addressed to a rheumatologist for his known pain: after 3 consultations with blood tests and Rx (all negative!!), an hypothetical diagnosis of rheumatoid disease was evocated….(Eular test: 2 pts!!)

1. Abstract
1.1. Background Context: Over the last 50 years, the developments emerged in the diagnosis and treatment of supracondylar humerus fractures (SHF) have significantly reduced the number of severe complications while certain complications with dreadful evolution, such as elbow stiffness or Volkmann’s syndrome, have completely vanished. During my residency, in 1982, on the suggestion of Prof. Pesamosca, I have performed a surgical intervention for a patient diagnosed with SHF. At that time, the PP with K -wires were placed in an inverted V. The most common complication was the loss of reduction and the consequences seen in many cases were cubitus varus, cubitus valgum, abchilosis or stiffness. The inverted V-fixation was taken from Prof. Vereanu. I asked his permission to cross K-wires and he agreed. It was the first X-fixation.