1. Abstract 1.1. Purpose Encysted adiponecrosis is a benign subcutaneous lesion characterized histologically by encapsulated fat necrosis. Our purpose was to present and discuss an atypical case of adiponecrosis revealed by a chronic hard mass of soft tissue becoming painful, associated with an erythematous skin nodule of undetermined origin.
1. Abstract A 57-year-old male was admitted to our Hospital on March 2020 for SARS-Cov2 related interstitial pneumonia. Chest x-ray showed a bilateral interstitial-alveolar pneumonia and Blood gas analysis (BGA) in room air highlighted a severe respiratory failure (pO2 46 mmHg, pH 7.41). Due to clinical and biohumoral worsening (stable CRP at 24 mg/dL), tocilizumab (800mg) was performed after acquiring patient’s informed consensus. In the evening, after 96 hours of hospitalization, the patient presented a clear hyposthenia / hemiparesis of the right hemisome whit hyperreflexia, confusion and slowed speech.
Complement Enhances the Pathogenesis in Autoinflammation Via Induction of A Pro-Inflammatory Microenvironment
1. Introduction The complement system is a complex part of the innate immune system and consists of more than thirty different proteins present in the plasma and on cell membranes. Complement can be activated via three different pathways and may play a role in triggering the NLRP3 inflammasome . Inflammasomes are essential components in innate immunity. A group of inflammasome disorders has been associated with Autoinflammatory Diseases (AIDs).
1. Abstract Congenital hepatic fibrosis (CHF) and Caroli disease are two rare genetic diseases. When both conditions are present simultaneously, is known as Caroli syndrome. The main complications are cholangitis and those related to portal hypertension. An uncommon complication but devastating of this diseases is cholangiocarcinoma, with few cases reported in the literature.
Flavones and Phenolic Acids as Potential Inhibitor of B16F10 Melanoma Cells Growth and Modulator of Melanogenesis
1. Abstract Pigmentation disorders leading to discoloration or hyperpigmen-tary of underlying tissue occur widely and gain interest. This study is within the framework of strategies under-developing safe com-pounds to modulate melanognonesis pathway. Phenolic acids and flavones were tested for their effects, on the viability in murine melanoma (B16-F10) and in primary human keratinocyte (PHK). Flavones, luteolin and apigenin exhibited significant anti-prolifer-ative activity against cell skin cancer B16-F10, while phenolic ac-ids, caffeic, ferulic and coumaric acids, induced slight inhibition.
1. Abstract 1.1. Background: Sinus of Valsalva injury, either due to congenital defect or major traumatic events, was known to be rare. 1.2. Case presentation: A 44-year-old male and 68-year-old female underwent coronary angiography and experienced sinus of Valsalva injury at our hospital, that confirmed with computed tomography scanning of aorta with contrast and was successfully managed conservatively with continuous pericardial drainage and antiplatelet therapy.
1. Abstract Alagille syndrome (ALGS) is a multisystem autosomal dominant disorder attributed to defects in the Notch signaling pathway. The mutation of Jagged 1 (JAG1) gene on chromosome 20 has been identified as the underlying cause of this syndrome.
1. Abstract Kawasaki disease (KD) is one of the most common etiologies of acquired heart disease among children worldwide with unknown pathogen. Early recognition and establishing the diagnosis help the clinical pediatrics practitioner delivering intravenous immunoglobulin treatment promptly, which plays the most important part of reducing the risk of developing coronary artery abnormalities. Recurrent KD is not uncommon, and needs to be carefully differentiated from various pathogen. Since the diagnosis based on patient’s clinical presentations, incomplete or atypical KD has dramatically increased the difficulties of diagnosis.