Volume 7

Multiple-Scale Computational Studies of Redox-Controlled Supramolecular Co-Assembly Nanoplat form: Toward Immunochemotherapy-Driven Antitumor Augment

Clinical Image

1. Abstract Programmed cell death protein 1 (PD1)/programmed death ligand 1 (PD-L1) blockades provide an effective and safe therapeutic option in the field of refractory cancer therapy. However, not more than 30% response rate of most cancers seriously impedes their therapeutic efficacy. Previous investigations have proved the effectiveness of combining chemotherapy with immunotherapy for unsatisfactory response to anti-PD1.

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Cytokine Storm Syndrome in COVID-19 Patients: Characteristics and Diagnosis

Review Article

1. Abstract Cytokine storm syndrome (CSS) is a critical condition induced by a cascade of cytokine activation, characterized by overwhelming systemic inflammation, hyperferritinaemia, haemodynamic instability and multiple organ failure. At the end of 2019, the disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in Wuhan, China, and rapidly developed into a global pandemic.

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Impact of Anesthetics on the ST Segment Among Patients with Brugada Syndrome: Case Series

Case Report

1. Abstract 1.1. Aim: Brugada syndrome is a canalopathy causing rhythmic sudden death. The use of many drugs such as anesthetics but also many analgesics are contraindicated or not recommended in this pathology. The literature shows a low-level evidence while clinical experience may bring additional knowledge.

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Case of Anthrax Abdominal Form in Kazakhstan

Short Communication

1. Introduction Anthrax is a dangerous zoonotic infection that is transmitted from farm animals to humans, when cutting, butchering infected animals, contact with meat and other animal products. Infection occurs by contact, alimentary, aerogenic pathways, while developing corresponding clinical forms – skin /ulcerative, abdominal / intestinal, pulmonary /pneumonic Kazakhstan is an anthrax-endemic territory, cases of this infection are registered almost annually [1]. DOI : http://dx.doi.org/10.47829/ACMCR.2021.71801

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Wen Dan Tang: A Potential Jing Fang Decoction for Headache Disorders

Research Article

1. Abstract 1.1 Background: Chinese herbal medicine is considered relatively safe, inexpensive, and easily accessible. Furthermore, it is becoming increasingly popular in the western countries. Wen Dan Tang, a Jing Fang ancient classical Chinese herbal formula, with a broad indication profile, has been used for several centuries in China to treat various illnesses.

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Loop –Mediated Isothermal Amplification (LAMP) Based POINT-OF-CARE for Rapid Detection of Pathogens Recent Development and Future Out Look

Research Article

1. Abstract Infectious diseases, including foodborne diseases, to this day remain a major health threat worldwide. Molecular diagnostics, based on nucleic acid (NA) amplification technologies, are in the forefront for the detection of pathogens. Polymerase chain reaction (PCR) is one of the most widely used methods for nucleic acid amplification in pathogen diagnostic.

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Deprescribing of Benzodiazepines in the Elderly Using A 3Es Model: A Patient Centered Approach

Research Article

1. Abstract Benzodiazepines use in the elderly are associated with morbidity including increased falls, fractures, and mortality. The common reason for re-prescribing benzodiazepine by physicians is dependency. Our project proposal aims to enhance medication safety in the elderly. It requires a multidisciplinary approach and patient-centred care focusing on benzodiazepine deprescribing using the 3Es model of Educating, Empowering, and Engaging. The education starts with patients, providers, and the community about benzodiazepine adverse effects on the elderly and provides alternative approaches for symptoms management. DOI : http://dx.doi.org/10.47829/ACMCR.2021.71701

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Hepatic Artery Aneurysm Masquerading as Abdominal Pain in a Child: A Rare Case Report

Case Report

1. Abstract 1.1. Background: Hepatic artery aneurysm is a rare clinical entity amongst children accounting for 20 % of all the splanchnic artery aneurysms, and if neglected could lead to catastrophic events.

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Association between Body Mass Index and Severity According of Classification of Thyroid Cancer

Research Article

1. Abstract 1.1. Purpose: Obesity is associated with aggressive pathological features and poor clinical outcomes in breast and prostate cancers. However, the associations between excess weight and prognostic factors for thyroid cancer are uncertain. This study aimed to evaluate the associations between body mass index (BMI) and severity according of classification of thyroid cancer. DOI : http://dx.doi.org/10.47829/ACMCR.2021.71603

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My Lynch Syndrome Survivor’s Story – Duke “C” Colon Cancer While Pregnant

Case Report

1. Abstract Lynch Syndrome is a familial disease, caused by a germline pathogenic variant in the mismatch repair genes: EPCAM, MLH1, MSH2, MSH6, and PMS2. Lynch Syndrome poses a lifetime-risk for related cancers such as colon, endometrial, ovarian and gastric, due to a DNA sequencing error in codon region MSH2. I (Savard, present author) inherited exon 15, variant c.2633_2634delAG, interpreted as pathogenic. Chances or inheriting Lynch from a parent is 50%. In 1981, my son was just born. I was diagnosed with colon cancer. Our small-town doctors engaged, and my parents drove 1250 miles to help care for us. In 2021, I have retired from a professional career in biology and wonder; did my son contribute to my long life? Did my transition from female to male help avert a cancer (i.e., removal of breast tissue, ovaries and uterus)? Can Lynch Syndrome be averted or cured? This narrative is my story.

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