1. Abstract 1.1. Background: Hepatic artery aneurysm is a rare clinical entity amongst children accounting for 20 % of all the splanchnic artery aneurysms, and if neglected could lead to catastrophic events.
1. Abstract 1.1. Purpose: Obesity is associated with aggressive pathological features and poor clinical outcomes in breast and prostate cancers. However, the associations between excess weight and prognostic factors for thyroid cancer are uncertain. This study aimed to evaluate the associations between body mass index (BMI) and severity according of classification of thyroid cancer.
1. Abstract Lynch Syndrome is a familial disease, caused by a germline pathogenic variant in the mismatch repair genes: EPCAM, MLH1, MSH2, MSH6, and PMS2. Lynch Syndrome poses a lifetime-risk for related cancers such as colon, endometrial, ovarian and gastric, due to a DNA sequencing error in codon region MSH2. I (Savard, present author) inherited exon 15, variant c.2633_2634delAG, interpreted as pathogenic. Chances or inheriting Lynch from a parent is 50%. In 1981, my son was just born. I was diagnosed with colon cancer. Our small-town doctors engaged, and my parents drove 1250 miles to help care for us. In 2021, I have retired from a professional career in biology and wonder; did my son contribute to my long life? Did my transition from female to male help avert a cancer (i.e., removal of breast tissue, ovaries and uterus)? Can Lynch Syndrome be averted or cured? This narrative is my story.
1. Abstract We report a case of slowly progressive Becker’s muscular dystrophy in a 52-year-old man who required cardiac transplantation for intractable congestive heart failure. A referral was made concerning prognosis of his muscular dystrophy in the multidisciplinary approach to transplant. A review of the literature provides limited guidance on cardiac transplantation in patients with muscular dystrophy although this procedure appears to be well-tolerated in those with Becker’s muscular dystrophy. Formal assessments and neuromuscular follow-up have not been clearly documented in patients having cardiac transplantation, and robust clinical evidence or guidance in this area is lacking.
A Case of Methotrexate-Associated Lymphoproliferative Disorder After Resection of an Accidentally Detected Enlarged Thyroid Tumor
1. Abstract 1.1. Introduction: We herein present a case of methotrexate-associated lymphoproliferative disorder (MTX-LPD) with a diagnosis of an 8-mm thyroid tumor of class III cytology that grew three times larger during 2 years 8 months before resection.
1. Abstract Inhaled tobramycin is a treatment option to treat respiratory infections caused by Pseudomonas aeruginosa, allowing high concentrations of this antibiotic in the respiratory tract, reducing secondary toxicity. However, nephrotoxicity is possible due to drug absorption, especially in patients with previous kidney disease. We explain the case of a 68-year-old man with a kidney transplant who presents acute kidney failure after receiving inhaled tobramycin.
Refractory Vasospasm and Arterial Ischemic Stroke in Meningoencephalitis: Novel Intrathecal Nitroprusside Treatment
1. Abstract 1.1. Background Acute stroke in bacterial meningitis in children contributes to high morbidity and mortality. The incidence of stroke in pediatric meningitis is varied, with reports between 8-42%, and associated mortality as high as 25%. The majority of these are arterial ischemic strokes (80-93%). Cerebral arterial vasospasm has been proposed. We present the first case of intrathecal nitroprusside used to treat refractory vasospasm in a child with bacterial meningoencephalitis complicated by acute ischemic stroke.
1. Abstract Cholangiocarcinoma (CHOL) is the most common malignant tumor of hepatobiliary system. The present study investigated the clinical significance and biological functions of LOXL1-AS1 in CHOL. The poor survival in CHOL has a probable prognostic molecular marker known as the LOXL1-AS1, and LOXL1-AS1 may be an important regulator of immune cell infiltration.
Publications Trends in Major Anesthesiology Journals: A 20-Year Analysis of Five Top-Ranked Journals in The Field
1. Abstract 1.1. Background: With the intention to quantify the importance of a medical journal, the impact factor (IF) was introduced. It has become a de facto fictive rating instrument of the importance of medical journals. Also, it is often used to asses the value of the individual publications within the specific journal. The aim of the present study was to analyze publication trends over 20 years in five high-ranked anesthesiology journals.
1. Abstarct Thalassemia is of the most frequent haemoglobinopathy that includes a heterogeneous group of inherited autosomal recessive pathologies caused by defective synthesis of globin subunit that comprise haemoglobin production. In β-thalassemia, insufficient quantities of β-globin chains are produced, causing ineffective erythropoiesis and microcytic hypochromic anaemia. The clinical severity of the disease, ranging from minor (or trait), intermedia to major forms (also known as Cooley anaemia), depending on the severity of the reduction in β-globin synthesis and the consequences of hyper haemolysis leading to iron overload and extramedullary erythropoiesis [1, 2].