Volume 8

Genetic Polymorphic Impact of Metabolizing Enzyme (CYP3A4 and UGT1A4 genes) on Anastrazole Response in Iraqi Breast Cancer Women

Research Article

1. Abstract 1.1. Background and Objective: Anastrazole is an aromatase inhibitor used widely in therapy of breast cancer and has been metabolized by CYP3A4 and UGT1A4 in liver. Breast cancer is the most common cancer type in worldwide and the second causes of death after lung cancer and the one of therapy that use in its treatment is aromatase inhibiter, anastrazole has been indicated CYP3A1 and UGT1A4 are the main metabolizing enzyme, so the interindividual variation in anastrazole response are due to polymorphism of these gene. We have aimed to determine whether CYP3A4*22 and UGT1A4*2 single nucleotide polymorphisms can have affected on the response of anastrazole.

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Concomitant Diseases in a Complex Case of Peritonitis after Stapled Trans Anal Rectal Resection (Starr) in Obstructed Defecation Syndrome (Ods). Role of a Diagnostic and Therapeutic Multidisciplinary Approach

Case Report

1. Abstract Approximately 0.06-2.3% of the population presents a Jejunal and Ileal Diverticular (JID) disease, of whom approximately 10% develop life-threatening complications such as inflammation, perforation, bleeding, obstruction, and malabsorption [1-3, 9]. Although only 40% of these patients remain asymptomatic, jejunal diverticulosis is usually not clinically suspected. The diagnosis of this condition is usually made incidentally or after the onset of complications as hemorrhage, diverticulitis, or obstruction. We report the case of a 45-year-old patient that presented, after a Stapled Trans Anal Rectal Resection (STARR) for an Obstructed Defecation Syndrome (ODS), a not related acute abdominal pain syndrome. In such complicated clinical cases has been mandatory to have a multidisciplinary approach.

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Mucoepidermoid Carcinoma of Parotid Gland: 2 Cases and Literature Review

Case Report

1. Abstract Mucoepidermoid Carcinoma (MEC) of the salivary gland accounted for 5% of all salivary gland tumors and 20% of all malignant salivary gland tumors [1]. About 50% of salivary gland Mucoepidermoid carcinoma occurred in the parotid gland, and 45% occurred in small salivary glands of the maxillary and buccal mucosa [2]. The main age of onset is between 35-65. However, there are few reports at home and abroad, and even fewer reports on the ultrasonic characteristics and pathological basis of a single disease [3].

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A Case of Giant Intrapericardial Teratoma of the Heart in an Infant with a Favorable Outcome

Clinical Case

1. Abstract Primary cardiac tumors in newborns and young children are rare, but they affect significantly their health and can be the cause of sudden death. These tumors compromise the integrity and function of adjacent cardiac structures, causing often impaired blood flow, causing myocardial dysfunction, valve failure, arrhythmias, respiratory changes, and cyanosis. We present a clinical case of an oversized intrapericardial teratoma diagnosed in a child aged 19 months, which ended in recovery. Proper diagnosis and surgical treatment saved the child from lethal outcome even in a case of a large tumor.

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Schwannoma With Extensive Vascular Hyperplasia in the Breast Mimicking Angiosarcoma

Case Report

1. Abstract Schwannoma with extensive vascular hyperplasia in the breast is extremely rare. It is typically benign and slow growing. Here, we describe a case of 54-year-old woman underwent complete resection of a tumor measuring 2.5×2.0 cm in the breast. The tumor was composed with spindle cell component and abundant blood vessel component. The subcapsular cellular component was composed of spindleshaped cells arranged in bundle and palisading pattern.

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Diffuse Cystic Airspaces in Bilateral Lungs Caused by Anlotinib

Clinical Image

1. Description A 31-year-old woman, who was diagnosed of stage IVB pulmonary adenocarcinoma in July, 2018, accepted first-line treatment of afatinib and second-line treatment of platinum-based doublet chemotherapy. On April 26th, 2019, the patient complained with occasional dry cough and was admitted to the hospital to evaluate the therapeutic effect of previous chemotherapy.

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Solitary Gastric Metastasis of Breast Invasive Lobular Carcinoma

Case Report

1. Abstract A 52-year-old female patient with solitary gastric metastasis from breast invasive lobular cancer without any other organ involvement is presented in this study. Solitary gastric metastasis of breast cancers is very rare. It can be diagnosed incidentally by endoscopic biopsy and immuno-histo-chemical analysis. Symptoms and clinical findings are not different from primary gastric cancers. Prognosis of solitary gastric metastasis is good after surgical treatment according to patients with systemic metastasis.

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Mandibular AV Malformation: Life-Threatening Bleeding from the Mouth Managed by Endovascular Intervention Complicated by Acute Ischemic Stroke on Table. Case Report

Case Report

1. Abstract Arteriovenous malformations (AVM) of mandibula are rare abnormal congenital vascular condition that can result in serious complications. Although, various treatment options have been advocated in the literature, there seems to be no complete consensus on a suitable treatment option in these cases. Here, we describe a case of mandibular AVM, who has presented with massive oral bleeding, treated successfully by embolization of the bilateral external carotid arteries and the left superior thyroid artery. During the procedure, the patient developed symptoms of acute ischemic stroke that was diagnosed and managed during the same session by endovascular techniques.

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Laparoscopic Resection of Large Endo-Cervical Polyp Through Posterior Colpotomy as an Alternative Access to Vagina in Virgin Patients

Case Report

1. Abstract Endometrial polyps have been involved in about 50% of patients with abnormal uterine bleeding and 35% of infertile patients. Management of pedunculated endocervical myoma or polyp normally requires intervention via the vaginal route. Laparoscopy provides safe alternative in patients demanding hymenal integrity. A 28-year-old, nulliparous virgin woman who presented with anemia secondary to heavy menstrual bleeding for five years. Pelvic ultrasound and MRI showed a 3.2 x 2.4 cm mass at the upper vagina it concluded that the mass likely to be pedunculated uterine fibroid, other differential diagnosis including endometrial polyp. Due to the patient’s consistent desire for preserving hymenal integrity, laparoscopic posterior colpotomy was performed and the mass was removed successfully.

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First Case of Hb Agrinio with – –SEA Causing Hb H Disease in an Individual from China: A Case Repot and Review the Literature

Case Report

1. Abstract 1.1. Background: Hb Agrinio (α29(B10) Leu→Pro), is an unstable abnormal hemoglobin (Hb), which was identified in the α2-globin gene with the variant c.89T>C, and has been reported only in individuals of Greek, Cypriot, Macedonian and Spanish origin. The variant with HBA2: c.89T>C can result in an α+ allele leading to a mild degree of red blood cell damage. The phenotype of Hb Agrinio results in microcytic hypochromic anemia.

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