Volume 8

The Role of Bone Mineral Density Assessment in Health-Related Quality of Life in Postmenopausal Han Chinese Women Prior to Clinic Diagnosis of Osteoporosis

Historical Study

1. Abstract
1.1. Purpose: Osteoporosis is a systemic skeletal disease and strongly associated with reduced quality of life (QoL). The aim of the study was to explore BMD that might serve as index of health-related QoL (HRQoL), or the relationship between bone mineral density (BMD) and HRQoL in postmenopausal Han Chinese women prior to diagnosis of osteoporosis.

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Unerupted Teeth, A New Symptom of Amyloidosis?

Case Report

1. Abstract
1.1. Background: Amyloidosis are rare diseases related to the pathological aggregation and accumulation of misfolded proteins in the extracellular space generating insoluble deposits. This may occur in almost any tissue and organ, leading to severe structural damages and functional impairments. Oral manifestations are frequent in systemic amyloidosis and represent 9% of the localized forms. The most common are: macroglossia, cutaneous or oral mucosa lesions (petechiae, xerostomia) and periodontal involvement. Teeth involvement (pain, mobility or loss) is only described as secondary to periodontal alterations. Abnormalities of teeth eruption have not yet been reported in amyloidosis.
1.2. Case Report: In this case report we highlighted uncommon oral manifestations – multiple mandibular impacted teeth and cystic peri-coronary bone lesions – in a 58-year-old patient, with an established diagnosis of severe hereditary ATTR amyloidosis, and illustrated the difficulties of etiologic diagnosis and therapeutic management of such oral and dental lesions in this context.

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Commentary: Defecation Delay in Patients After Lung Tumor Surgery: A Prospective Nested Case-Control Study

Short Commentary

Dear Editors
This is a brief commentary to our article “Defecation delay in patients after lung tumor surgery: a prospective nested case-control study” [1]. The author Chen used to be a resident and rotate in different departments of surgery and find that discomfort related to defecation is quite common in patients receiving various operation under general anesthesia. Even operations not associated with gastrointestinal tract like thyroidectomy may develop a need for laxatives though patients recovered quickly after the procedure. However, this problem is usually not fully appreciated and just a few studies focused on it. The majority of such studies were associated with orthopedic surgery and focused on chronic constipation in a long term after surgery [2,3]. Researchers tended to believe that decrease in activity especially walking out of bed for a period and the use of opioids to stop the pain are the main causes of this problem [4,5]. Different from the studies above, we aimed at acute constipation, or in the other words, discomfort related to defecation in a short period after the operation. To get further knowledge about this problem, we conducted a prospective and observational study in nested case-control design, which means the outcome we care about will appear as the study proceed. In the very beginning, we wanted to simplify our protocol for the definition of constipation is so complicated and there is no unified definition of the discomfort related to defecation after surgery.

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After Sequential Therapy with First and Third Generation EGFR-Tkis, A Patient Acquired EGFR G719A Mutation and Responded to Afatinib, and Then, Acquired EGFR T790M Mutation When Developed Resistance to Afatinib: A Case Report

Case Report

1. Abstract
NSCLC patients who had sensitive EGFR mutation had great possibility to get benefit from EGFR-TKIs. But this efficacy was relied on related EGFR mutation, if related EGFR mutation changed, resistance would happened. In our report, we did next generation sequencing(NGS) each time the patient had progression. We observed the patient acquired rare mutation after the resistance to third-generation EGFR-TKIs and this mutation was sensitive to second-generation EGFR-TKIs. And after the resistance to second-generation EGFR-TKIs, the patient had T790M EGFR mutation again and third-generation EGFR-TKIs could be continue taken.

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SARS-Cov2 and limb Ischemia

Case Report

1. Abstract
Patients with severe acute respiratory syndrome coronavirus 2 (SARS-Cov2) infection mainly present severe pneumonia associated with complications related to cytokine storm syndrome. So, it was associated with thrombotic incidents like acute limb ischemia and pulmonary embolism.

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A Road from Coronary to Pulmonary: A Rare Imaging Presentation

Case Report

1. Abstract
Tetralogy of Fallot (TOF) is the most common cyanotic congenital heart disease. Its association with Pulmonary Atresia is considered to be the most severe form, the diagnosis of which plays an important role in determination of the treatment protocol. In such cases, systemic vascular channels called Major Aortopulmonary Collateral Arteries (MAPCA’s) develop from aorta and its major branches to supply and maintain the pulmonary circulation. Such patients commonly undergo a Cardiac CT as an imperative pre-operative investigation for detailed information of these collaterals which helps plan further management. Here, we present a Case Report of an adult female patient with Pentalogy of Fallot wherein, a Cardiac CT showed the presence of dilated coronary-to-pulmonary collateral circulation. i.e. CAPA apart from the normally visualized MAPCA’s, an extremely rare occurrence.

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Prevalence and Determinants of Distress Among Residents During COVID Crisis

Research Article

1. Abstarct

1.1. Background and Objectives

Residents are predisposed to develop distress, burnout, and depression. With COVID-19, new stressful working conditions were imposed. This study aims to assess the impact of COVID-19 on residents’ wellbeing in France.

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Ulcerative Colitis with Aseptic Abscesses Controlled by Vedolizumab: A Case Report

Case Report

1. Abstract

1.1. Introduction: Aseptic abscesses (AAs) are neutrophilic infiltrative lesions that often coincide with systemic inflammatory disorders such as inflammatory bowel diseases (IBD). According to recent literature, medical therapies in IBD with AAs include corticosteroid, immunosuppressants and anti-TNFα biologics.

1.2. Report: Herein we reported a patient of ulcerative colitis with AAs and other extraintestinal manifestations treated with vedolizumab that showed a very inspiring outcome.

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A Metastatic Melanoma Patient with Spontaneous Melanoma-Associated Vitiligo Survived for up to 7 Years and 5 Months: A Case Report

Case Report

1. Abstract

1.1. Background: Malignant melanoma is a highly malignant tumor caused by abnormal proliferation of melanoma cells in the skin and mucous membranes, with a poor prognosis after metastasis. Skin melanocytes are gradually destroyed in vitiligo patients. There is a certain correlation between these two diseases: In these two conditions, cytotoxic T lymphocytes that target autoantigens shared by normal melanocytes and melanoma cells have been found. Spontaneous melanoma-associated vitiligo was relatively rare before melanoma was diagnosed, and its pathogenesis and prognosis were rarely studied. The cases we reported is extremely rare for a patient to have a metastasis of melanoma that lasts much longer than the moderate survival time of a patient with malignant melanoma.

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Giant Gallstone, Rare Cause for Conversion to open Cholecystectomy from Laparoscopic

Case Report

1. Abstract

1.1. Background: Gallbladder stones is one of the most common disease of the digestive system. Giant gallbladder stone is rare and subject to technical difficulties in laparoscopic cholecystectomy with high rate of conversion to open cholecystectomy.

1.2. Aim: This is to report one case of a giant gallstone treated with open technique after the trials of laparoscopic technique. Mentioning of some technical difficulties asscociated with laparoscopic approach in large gallbladder stones.

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